Anti-TRMT1 antibody (460-659) (STJ29196)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TRMT1 (460-659) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRMT1 |
| Gene ID | 55621 |
| Uniprot ID | TRM1_HUMAN |
| Immunogen Region | 460-659 |
| Immunogen Sequence | PSLLQLRSALLHADFRVSLS HACKNAVKTDAPASALWDIM RCWEKECPVKRERLSETSPA FRILSVEPRLQANFTIREDA NPSSRQRGLKRFQANPEANW GPRPRARPGGKAADEAMEER RRLLQNKRKEPPEDVAQRAA RLKTFPCKRFKEGTCQRGDQ CCYSHSPPTPRVSADAAPDC PETSNQTPPGPGAAAGPGID |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 460-659 of human TRMT1 (NP_060192.1). |
Additional Info
| Post Translational Modifications | (Microbial infection) Cleaved between Gln-530 and Ala-531 by the 3C-like proteinase nsp5 from human coronavirus SARS-CoV-2, leading to its inactivation. |
| Function | Dimethylates a single guanine residue at position 26 of most nuclear- and mitochondrial-encoded tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. tRNA guanine(26)-dimethylation is required for redox homeostasis and ensure proper cellular proliferation and oxidative stress survival. |
| Protein Name | TrnaGuanine(26-N(2-DimethyltransferaseTrna 2 -2-Dimethylguanosine-26 MethyltransferaseTrna Methyltransferase 1Htrm1Trna(Guanine-26 -N(2-N(2 MethyltransferaseTrna(M(2 -2g26dimethyltransferase |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | Isoform 1: MitochondrionIsoform 3: NucleusCytoplasm |
| Alternative Antibody Names | Anti-Trna antibodyAnti-Guanine(26-N(2-Dimethyltransferase antibodyAnti-Trna 2 -2-Dimethylguanosine-26 Methyltransferase antibodyAnti-Trna Methyltransferase 1 antibodyAnti-Htrm1 antibodyAnti-Trna(Guanine-26 -N(2-N(2 Methyltransferase antibodyAnti-Trna(M(2 -2g26dimethyltransferase antibodyAnti-TRMT1 antibody |
Information sourced from Uniprot.org