| Host: | Goat |
| Applications: | Pep-ELISA |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-TRIP4/ASC1 (Internal) is suitable for use in ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000. WB: Preliminary experiments in Human Testis, Thyroid gland and Ovary lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any fe |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | TRIP4 |
| Gene ID: | 9325 |
| Uniprot ID: | TRIP4_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_057297.2 |
| Immunogen Sequence: | RVEGRSWYTPHR |
| Function | Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation. Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. |
| Protein Name | Activating Signal Cointegrator 1 Asc-1 Thyroid Receptor-Interacting Protein 4 Tr-Interacting Protein 4 Trip-4 |
| Cellular Localisation | Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Organizing Center Centrosome Cytoplasmic Under Conditions Of Serum Deprivation Colocalizes With Nek6 In The Centrosome |
| Alternative Antibody Names | Anti-Activating Signal Cointegrator 1 antibody Anti-Asc-1 antibody Anti-Thyroid Receptor-Interacting Protein 4 antibody Anti-Tr-Interacting Protein 4 antibody Anti-Trip-4 antibody Anti-TRIP4 antibody Anti-RQT4 antibody |
Information sourced from Uniprot.org