Anti-TRIP4/ASC1 antibody (Internal) (STJ72992)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TRIP4/ASC1 (Internal) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments in Human Testis, Thyroid gland and Ovary lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any fe |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIP4 |
| Gene ID | 9325 |
| Uniprot ID | TRIP4_HUMAN |
| Accession Number | NP_057297.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | RVEGRSWYTPHR |
Additional Info
| Function | Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation. Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. |
| Protein Name | Activating Signal Cointegrator 1Asc-1Thyroid Receptor-Interacting Protein 4Tr-Interacting Protein 4Trip-4 |
| Cellular Localisation | NucleusCytoplasmCytosolCytoskeletonMicrotubule Organizing CenterCentrosomeCytoplasmic Under Conditions Of Serum DeprivationColocalizes With Nek6 In The Centrosome |
| Alternative Antibody Names | Anti-Activating Signal Cointegrator 1 antibodyAnti-Asc-1 antibodyAnti-Thyroid Receptor-Interacting Protein 4 antibodyAnti-Tr-Interacting Protein 4 antibodyAnti-Trip-4 antibodyAnti-TRIP4 antibodyAnti-RQT4 antibody |
Information sourced from Uniprot.org