Anti-TRIP4/ASC1 antibody (Internal) (STJ72992)

SKU:
STJ72992-100

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Host: Goat
Applications: Pep-ELISA
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-TRIP4/ASC1 (Internal) is suitable for use in ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: TRIP4
Gene ID: 9325
Uniprot ID: TRIP4_HUMAN
Immunogen Region: Internal
Accession Number: NP_057297.2
Immunogen Sequence: RVEGRSWYTPHR
Function Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation. Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation.
Protein Name Activating Signal Cointegrator 1
Asc-1
Thyroid Receptor-Interacting Protein 4
Tr-Interacting Protein 4
Trip-4
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule Organizing Center
Centrosome
Cytoplasmic Under Conditions Of Serum Deprivation
Colocalizes With Nek6 In The Centrosome
Alternative Antibody Names Anti-Activating Signal Cointegrator 1 antibody
Anti-Asc-1 antibody
Anti-Thyroid Receptor-Interacting Protein 4 antibody
Anti-Tr-Interacting Protein 4 antibody
Anti-Trip-4 antibody
Anti-TRIP4 antibody
Anti-RQT4 antibody

Information sourced from Uniprot.org

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