| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM45 (100-400) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM45 |
| Gene ID: |
80263 |
| Uniprot ID: |
TRI45_HUMAN |
| Immunogen Region: |
100-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human TRIM45 (NP_001139107.1). |
| Immunogen Sequence: |
QVDLPMGGVKALTIDHLAVN DVMLESLRGEGQGLVCDLCN DREVEKRCQTCKANLCHFCC QAHRRQKKTTYHTMVDLKDL KGYSRIGKPILCPVHPAEEL RLFCEFCDRPVCQDCVVGEH REHPCDFTSNVIHKHGDSVW ELLKGTQPHVEALEEALAQI HIINSALQKRVEAVAADVRT FSEGYIKAIEEHRDKLLKQL EDIRAQKENSLQLQKAQLEQ LLADMRTGVEFTEHLLTSG |
| Tissue Specificity | Expressed in skeletal muscle, brain, heart and pancreas. |
| Function | E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response. Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response. May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim45Ring Finger Protein 99 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim45 antibodyAnti-Ring Finger Protein 99 antibodyAnti-TRIM45 antibodyAnti-RNF99 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
