| Applications: | IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRIM45 |
| Gene ID: | 80263 |
| Uniprot ID: | TRI45_HUMAN |
| Immunogen Region: | 100-400 |
| Immunogen Sequence: | QVDLPMGGVKALTIDHLAVN DVMLESLRGEGQGLVCDLCN DREVEKRCQTCKANLCHFCC QAHRRQKKTTYHTMVDLKDL KGYSRIGKPILCPVHPAEEL RLFCEFCDRPVCQDCVVGEH REHPCDFTSNVIHKHGDSVW ELLKGTQPHVEALEEALAQI HIINSALQKRVEAVAADVRT FSEGYIKAIEEHRDKLLKQL EDIRAQKENSLQLQKAQLEQ LLADMRTGVEFTEHLLTSG |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human TRIM45 (NP_001139107.1). |
| Tissue Specificity | Expressed in skeletal muscle, brain, heart and pancreas. |
| Function | E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response. Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response. May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim45Ring Finger Protein 99 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim45 antibodyAnti-Ring Finger Protein 99 antibodyAnti-TRIM45 antibodyAnti-RNF99 antibody |
Information sourced from Uniprot.org
