Host: |
Rabbit |
Applications: |
IHC/IF/ELISA |
Reactivity: |
Human/Rat/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-Tripartite motif-containing protein 16 (31-80 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
TRIM16 |
Gene ID: |
10626 |
Uniprot ID: |
TRI16_HUMAN |
Immunogen Region: |
31-80 aa |
Specificity: |
TRIM16 Polyclonal Antibody detects endogenous levels of TRIM16 protein. |
Immunogen: |
The antiserum was produced against synthesized peptide derived from the human TRIM16 at the amino acid range 31-80 |
Post Translational Modifications | Phosphorylated by ULK1. Auto-ubiquitinates via its B-Boxes. |
Function | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. |
Protein Name | Tripartite Motif-Containing Protein 16E3 Ubiquitin-Protein Ligase Trim16Estrogen-Responsive B Box Protein |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 16 antibodyAnti-E3 Ubiquitin-Protein Ligase Trim16 antibodyAnti-Estrogen-Responsive B Box Protein antibodyAnti-TRIM16 antibodyAnti-EBBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance