| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Tripartite motif-containing protein 16 (31-80 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRIM16 |
| Gene ID: | 10626 |
| Uniprot ID: | TRI16_HUMAN |
| Immunogen Region: | 31-80 aa |
| Specificity: | TRIM16 Polyclonal Antibody detects endogenous levels of TRIM16 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TRIM16 at the amino acid range 31-80 |
| Post Translational Modifications | Phosphorylated by ULK1. Auto-ubiquitinates via its B-Boxes. |
| Function | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. |
| Protein Name | Tripartite Motif-Containing Protein 16E3 Ubiquitin-Protein Ligase Trim16Estrogen-Responsive B Box Protein |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 16 antibodyAnti-E3 Ubiquitin-Protein Ligase Trim16 antibodyAnti-Estrogen-Responsive B Box Protein antibodyAnti-TRIM16 antibodyAnti-EBBP antibody |
Information sourced from Uniprot.org