| Short Description : | Rabbit polyclonal TRH (25-230) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRH |
| Gene ID: | 7200 |
| Uniprot ID: | TRH_HUMAN |
| Immunogen Region: | 25-230 |
| Immunogen Sequence: | QPEAAQQEAVTAAEHPGLDD FLRQVERLLFLRENIQRLQG DQGEHSASQIFQSDWLSKRQ HPGKREEEEEEGVEEEEEEE GGAVGPHKRQHPGRREDEAS WSVDVTQHKRQHPGRRSPWL AYAVPKRQHPGRRLADPKAQ RSWEEEEEEEEREEDLMPEK RQHPGKRALGGPCGPQGAYG QAGLLLGLLDDLSRSQGAEE KRQHPG |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 25-230 of human TRH (NP_009048.1). |
| Tissue Specificity | Hypothalamus. Expressed in the hair follicle epithelium (at protein level). |
| Function | As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes. |
| Protein Name | Pro-Thyrotropin-Releasing HormonePro-TrhProthyroliberin Cleaved Into - Thyrotropin-Releasing HormoneTrhProtirelinTsh-Releasing FactorThyroliberinThyrotropin-Releasing FactorTrf |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pro-Thyrotropin-Releasing Hormone antibodyAnti-Pro-Trh antibodyAnti-Prothyroliberin Cleaved Into - Thyrotropin-Releasing Hormone antibodyAnti-Trh antibodyAnti-Protirelin antibodyAnti-Tsh-Releasing Factor antibodyAnti-Thyroliberin antibodyAnti-Thyrotropin-Releasing Factor antibodyAnti-Trf antibodyAnti-TRH antibody |
Information sourced from Uniprot.org
