| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TPBG |
| Gene ID: | 7162 |
| Uniprot ID: | TPBG_HUMAN |
| Immunogen Region: | 32-350 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-350 of human 5T4 (NP_006661.1). |
| Immunogen Sequence: | SSPTSSASSFSSSAPFLASA VSAQPPLPDQCPALCECSEA ARTVKCVNRNLTEVPTDLPA YVRNLFLTGNQLAVLPAGAF ARRPPLAELAALNLSGSRLD EVRAGAFEHLPSLRQLDLSH NPLADLSPFAFSGSNASVSA PSPLVELILNHIVPPEDERQ NRSFEGMVVAALLAGRALQG LRRLELASNHFLYLPRDVLA QLPSLRHLDLSNNSLVSLTY VSFRNLTHLESLHLEDNAL |
| Tissue Specificity | Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma. |
| Post Translational Modifications | Highly glycosylated. |
| Function | May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. |
| Protein Name | Trophoblast Glycoprotein5t4 Oncofetal Antigen5t4 Oncofetal Trophoblast Glycoprotein5t4 Oncotrophoblast GlycoproteinM6p1Wnt-Activated Inhibitory Factor 1Waif1 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Trophoblast Glycoprotein antibodyAnti-5t4 Oncofetal Antigen antibodyAnti-5t4 Oncofetal Trophoblast Glycoprotein antibodyAnti-5t4 Oncotrophoblast Glycoprotein antibodyAnti-M6p1 antibodyAnti-Wnt-Activated Inhibitory Factor 1 antibodyAnti-Waif1 antibodyAnti-TPBG antibodyAnti-5T4 antibody |
Information sourced from Uniprot.org