| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TPBG (32-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TPBG |
| Gene ID: |
7162 |
| Uniprot ID: |
TPBG_HUMAN |
| Immunogen Region: |
32-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 32-350 of human 5T4 (NP_006661.1). |
| Immunogen Sequence: |
SSPTSSASSFSSSAPFLASA VSAQPPLPDQCPALCECSEA ARTVKCVNRNLTEVPTDLPA YVRNLFLTGNQLAVLPAGAF ARRPPLAELAALNLSGSRLD EVRAGAFEHLPSLRQLDLSH NPLADLSPFAFSGSNASVSA PSPLVELILNHIVPPEDERQ NRSFEGMVVAALLAGRALQG LRRLELASNHFLYLPRDVLA QLPSLRHLDLSNNSLVSLTY VSFRNLTHLESLHLEDNAL |
| Tissue Specificity | Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma. |
| Post Translational Modifications | Highly glycosylated. |
| Function | May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. |
| Protein Name | Trophoblast Glycoprotein5t4 Oncofetal Antigen5t4 Oncofetal Trophoblast Glycoprotein5t4 Oncotrophoblast GlycoproteinM6p1Wnt-Activated Inhibitory Factor 1Waif1 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Trophoblast Glycoprotein antibodyAnti-5t4 Oncofetal Antigen antibodyAnti-5t4 Oncofetal Trophoblast Glycoprotein antibodyAnti-5t4 Oncotrophoblast Glycoprotein antibodyAnti-M6p1 antibodyAnti-Wnt-Activated Inhibitory Factor 1 antibodyAnti-Waif1 antibodyAnti-TPBG antibodyAnti-5T4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
