| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TP53RK (1-253) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TP53RK |
| Gene ID: |
112858 |
| Uniprot ID: |
PRPK_HUMAN |
| Immunogen Region: |
1-253 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human TP53RK (NP_291028.3). |
| Immunogen Sequence: |
MAAARATTPADGEEPAPEAE ALAAARERSSRFLSGLELVK QGAEARVFRGRFQGRAAVIK HRFPKGYRHPALEARLGRRR TVQEARALLRCRRAGISAPV VFFVDYASNCLYMEEIEGSV TVRDYIQSTMETEKTPQGLS NLAKTIGQVLARMHDEDLIH GDLTTSNMLLKPPLEQLNIV LIDFGLSFISALPEDKGVDL YVLEKAFLSTHPNTETVFEA FLKSYSTSSKKARPVLKKL |
| Tissue Specificity | Highly expressed in testis. Weakly expressed in heart kidney and spleen. |
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. |
| Protein Name | Ekc/Keops Complex Subunit Tp53rkAtypical Serine/Threonine Protein Kinase Tp53rkNori-2Tp53-Regulating KinaseP53-Related Protein Kinase |
| Database Links | Reactome: R-HSA-6782315Reactome: R-HSA-6804756 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ekc/Keops Complex Subunit Tp53rk antibodyAnti-Atypical Serine/Threonine Protein Kinase Tp53rk antibodyAnti-Nori-2 antibodyAnti-Tp53-Regulating Kinase antibodyAnti-P53-Related Protein Kinase antibodyAnti-TP53RK antibodyAnti-C20orf64 antibodyAnti-PRPK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
