| Tissue Specificity | Highly expressed in testis. Weakly expressed in heart kidney and spleen. |
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. |
| Protein Name | Ekc/Keops Complex Subunit Tp53rkAtypical Serine/Threonine Protein Kinase Tp53rkNori-2Tp53-Regulating KinaseP53-Related Protein Kinase |
| Database Links | Reactome: R-HSA-6782315Reactome: R-HSA-6804756 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ekc/Keops Complex Subunit Tp53rk antibodyAnti-Atypical Serine/Threonine Protein Kinase Tp53rk antibodyAnti-Nori-2 antibodyAnti-Tp53-Regulating Kinase antibodyAnti-P53-Related Protein Kinase antibodyAnti-TP53RK antibodyAnti-C20orf64 antibodyAnti-PRPK antibody |
Information sourced from Uniprot.org
