Anti-TOP6BL antibody (93-143 aa) (STJ195089)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CK080 at the amino acid range 93-143
General Information
| Short Description | Rabbit polyclonal anti-Type 2 DNA topoisomerase 6 subunit B-like (93-143 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TOP6BL |
| Gene ID | 79703 |
| Uniprot ID | TO6BL_HUMAN |
| Immunogen | Synthesized peptide derived from the human CK080 at the amino acid range 93-143 |
| Immunogen Region | 93-143 aa |
| Specificity | This antibody detects endogenous levels of CK080 at Human |
Additional Info
| Function | Isoform 3: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. |
| Protein Name | Type 2 Dna Topoisomerase 6 Subunit B-LikeTop6b Like Initiator Of Meiotic Double Strand BreaksType 2 Dna Topoisomerase Vi Subunit B-LikeTopovibl |
| Database Links | |
| Cellular Localisation | ChromosomeLocalizes To Meiotic Chromosomes |
| Alternative Antibody Names | Anti-Type 2 Dna Topoisomerase 6 Subunit B-Like antibodyAnti-Top6b Like Initiator Of Meiotic Double Strand Breaks antibodyAnti-Type 2 Dna Topoisomerase Vi Subunit B-Like antibodyAnti-Topovibl antibodyAnti-TOP6BL antibodyAnti-C11orf80 antibody |
Information sourced from Uniprot.org