| Short Description : | Rabbit polyclonal anti-Type 2 DNA topoisomerase 6 subunit B-like (93-143 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TOP6BL |
| Gene ID: | 79703 |
| Uniprot ID: | TO6BL_HUMAN |
| Immunogen: | Synthesized peptide derived from the human CK080 at the amino acid range 93-143 |
| Immunogen Region: | 93-143 aa |
| Specificity: | This antibody detects endogenous levels of CK080 at Human |
| Function | Isoform 3: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. |
| Protein Name | Type 2 Dna Topoisomerase 6 Subunit B-LikeTop6b Like Initiator Of Meiotic Double Strand BreaksType 2 Dna Topoisomerase Vi Subunit B-LikeTopovibl |
| Database Links | |
| Cellular Localisation | ChromosomeLocalizes To Meiotic Chromosomes |
| Alternative Antibody Names | Anti-Type 2 Dna Topoisomerase 6 Subunit B-Like antibodyAnti-Top6b Like Initiator Of Meiotic Double Strand Breaks antibodyAnti-Type 2 Dna Topoisomerase Vi Subunit B-Like antibodyAnti-Topovibl antibodyAnti-TOP6BL antibodyAnti-C11orf80 antibody |
Information sourced from Uniprot.org
