• Western blot analysis of lysates from Jurkat cells, using TOP2B Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TOP2B Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-TOP2B antibody (1-50 aa) (STJ96068)

SKU:
STJ96068

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DNA topoisomerase 2-beta (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TOP2B
Gene ID: 7155
Uniprot ID: TOP2B_HUMAN
Immunogen Region: 1-50 aa
Specificity: Topo II Beta Polyclonal Antibody detects endogenous levels of Topo II Beta protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human TOP2B at the amino acid range 1-50
Post Translational Modifications (Microbial infection) Deubiquitinated by Epstein-Barr virus BPLF1.leading to stabilized SUMOylated TOP2A trapped in cleavage complexes, which halts the DNA damage response to TOP2A-induced double-strand DNA breaks. SUMOylated.
Function Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation.
Protein Name Dna Topoisomerase 2-Beta
Dna Topoisomerase Ii - Beta Isozyme
Database Links Reactome: R-HSA-4615885
Cellular Localisation Nucleus
Nucleolus
Nucleoplasm
Alternative Antibody Names Anti-Dna Topoisomerase 2-Beta antibody
Anti-Dna Topoisomerase Ii - Beta Isozyme antibody
Anti-TOP2B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance