| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TNFSF10 (1-281) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNFSF10 |
| Gene ID: |
8743 |
| Uniprot ID: |
TNF10_HUMAN |
| Immunogen Region: |
1-281 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human TNFSF10 (NP_003801.1). |
| Immunogen Sequence: |
MAMMEVQGGPSLGQTCVLIV IFTVLLQSLCVAVTYVYFTN ELKQMQDKYSKSGIACFLKE DDSYWDPNDEESMNSPCWQV KWQLRQLVRKMILRTSEETI |
| Tissue Specificity | Widespread.most predominant in spleen, lung and prostate. |
| Post Translational Modifications | Tyrosine phosphorylated by PKDCC/VLK. |
| Function | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 10Apo-2 LigandApo-2lTnf-Related Apoptosis-Inducing LigandProtein TrailCd Antigen Cd253 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinSecretedExists Both As Membrane-Bound And Soluble Form |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Ligand Superfamily Member 10 antibodyAnti-Apo-2 Ligand antibodyAnti-Apo-2l antibodyAnti-Tnf-Related Apoptosis-Inducing Ligand antibodyAnti-Protein Trail antibodyAnti-Cd Antigen Cd253 antibodyAnti-TNFSF10 antibodyAnti-APO2L antibodyAnti-TRAIL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
