Anti-TNFRSF11B antibody (22-280) (STJ29873)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TNFRSF11B (22-280) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNFRSF11B |
| Gene ID | 4982 |
| Uniprot ID | TR11B_HUMAN |
| Immunogen Region | 22-280 |
| Immunogen Sequence | ETFPPKYLHYDEETSHQLLC DKCPPGTYLKQHCTAKWKTV CAPCPDHYYTDSWHTSDECL YCSPVCKELQYVKQECNRTH NRVCECKEGRYLEIEFCLKH RSCPPGFGVVQAGTPERNTV CKRCPDGFFSNETSSKAPCR KHTNCSVFGLLLTQKGNATH DNICSGNSESTQKCGIDVTL CEEAFFRFAVPTKFTPNWLS VLVDNLPGTKVNAESVERIK RQHSSQEQTFQLLKLWKHQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 22-280 of human TNFRSF11B (NP_002537.3). |
Additional Info
| Tissue Specificity | Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung. |
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. The N-terminus is blocked. |
| Function | Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 11bOsteoclastogenesis Inhibitory FactorOsteoprotegerin |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 11b antibodyAnti-Osteoclastogenesis Inhibitory Factor antibodyAnti-Osteoprotegerin antibodyAnti-TNFRSF11B antibodyAnti-OCIF antibodyAnti-OPG antibody |
Information sourced from Uniprot.org