| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Transmembrane protein 59 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMEM59 |
| Gene ID: |
9528 |
| Uniprot ID: |
TMM59_HUMAN |
| Specificity: |
This antibody detects endogenous levels of TMEM59 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human TMEM59 |
| Function | Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. |
| Protein Name | Transmembrane Protein 59Liver Membrane-Bound Protein |
| Database Links | Reactome: R-HSA-9013407Reactome: R-HSA-9696273 |
| Cellular Localisation | Late Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneCell MembraneGolgi Apparatus MembraneMainly Localizes To Late Endosomes/LysosomesProbably First Exported To The Cell Surface And Then Actively Endocytosed To Transiently Localize In Early Endosomes On Its Way To The Late Endosomal/Lysosomal Compartment Where It Becomes Quickly Degraded |
| Alternative Antibody Names | Anti-Transmembrane Protein 59 antibodyAnti-Liver Membrane-Bound Protein antibodyAnti-TMEM59 antibodyAnti-C1orf8 antibodyAnti-HSPC001 antibodyAnti-UNQ169 antibodyAnti-PRO195 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
