Anti-TMEM59 antibody (STJA0008002)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human TMEM59
General Information
| Short Description | Rabbit polyclonal anti-Transmembrane protein 59 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMEM59 |
| Gene ID | 9528 |
| Uniprot ID | TMM59_HUMAN |
| Immunogen | Synthesized peptide derived from human TMEM59 |
| Specificity | This antibody detects endogenous levels of TMEM59 at Human, Mouse |
Additional Info
| Function | Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. |
| Protein Name | Transmembrane Protein 59Liver Membrane-Bound Protein |
| Database Links | Reactome: R-HSA-9013407Reactome: R-HSA-9696273 |
| Cellular Localisation | Late Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneCell MembraneGolgi Apparatus MembraneMainly Localizes To Late Endosomes/LysosomesProbably First Exported To The Cell Surface And Then Actively Endocytosed To Transiently Localize In Early Endosomes On Its Way To The Late Endosomal/Lysosomal Compartment Where It Becomes Quickly Degraded |
| Alternative Antibody Names | Anti-Transmembrane Protein 59 antibodyAnti-Liver Membrane-Bound Protein antibodyAnti-TMEM59 antibodyAnti-C1orf8 antibodyAnti-HSPC001 antibodyAnti-UNQ169 antibodyAnti-PRO195 antibody |
Information sourced from Uniprot.org