| Function | Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. |
| Protein Name | Transmembrane Emp24 Domain-Containing Protein 1Interleukin-1 Receptor-Like 1 LigandPutative T1/St2 Receptor-Binding ProteinP24 Family Protein Gamma-1Tp24P24gamma1 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneGolgi ApparatusCis-Golgi Network MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment Membrane |
| Alternative Antibody Names | Anti-Transmembrane Emp24 Domain-Containing Protein 1 antibodyAnti-Interleukin-1 Receptor-Like 1 Ligand antibodyAnti-Putative T1/St2 Receptor-Binding Protein antibodyAnti-P24 Family Protein Gamma-1 antibodyAnti-Tp24 antibodyAnti-P24gamma1 antibodyAnti-TMED1 antibodyAnti-IL1RL1L antibodyAnti-IL1RL1LG antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and TMED10 knockout (KO) 293T cells, using [KO Validated] TMED10 Rabbit polyclonal antibody (STJ11100063) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89133/357582/STJ11100063_1__14749.1713121714.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TMED10 knockout (KO) 293T cells, using [KO Validated] TMED10 Rabbit polyclonal antibody (STJ11100063) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.")
