Anti-TLN1 antibody (1-220) (STJ25860)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TLN1 (1-220) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TLN1 |
| Gene ID | 7094 |
| Uniprot ID | TLN1_HUMAN |
| Immunogen Region | 1-220 |
| Immunogen Sequence | MVALSLKISIGNVVKTMQFE PSTMVYDACRIIRERIPEAP AGPPSDFGLFLSDDDPKKGI WLEAGKALDYYMLRNGDTME YRKKQRPLKIRMLDGTVKTI MVDDSKTVTDMLMTICARIG ITNHDEYSLVRELMEEKKEE ITGTLRKDKTLLRDEKKMEK LKQKLHTDDELNWLDHGRTL REQGVEEHETLLLRRKFFYS DQNVDSRDPVQLNLLYVQAR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TLN1 (NP_006280.3). |
Additional Info
| Tissue Specificity | Isoform 2: Expressed at low to non-detectable levels in many tissues but highly expressed in skin and pancreas with other tissues including kidney cortex, endocervix, testis, pituitary, liver, and spleen also showing robust expression. |
| Function | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. |
| Protein Name | Talin-1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-381038Reactome: R-HSA-399955Reactome: R-HSA-445355Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell SurfaceCell JunctionFocal AdhesionColocalizes With Layn At The Membrane RufflesLocalized Preferentially In Focal Adhesions Than Fibrillar Adhesions |
| Alternative Antibody Names | Anti-Talin-1 antibodyAnti-TLN1 antibodyAnti-KIAA1027 antibodyAnti-TLN antibody |
Information sourced from Uniprot.org