| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TLN1 |
| Gene ID: | 7094 |
| Uniprot ID: | TLN1_HUMAN |
| Immunogen Region: | 1-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TLN1 (NP_006280.3). |
| Immunogen Sequence: | MVALSLKISIGNVVKTMQFE PSTMVYDACRIIRERIPEAP AGPPSDFGLFLSDDDPKKGI WLEAGKALDYYMLRNGDTME YRKKQRPLKIRMLDGTVKTI MVDDSKTVTDMLMTICARIG ITNHDEYSLVRELMEEKKEE ITGTLRKDKTLLRDEKKMEK LKQKLHTDDELNWLDHGRTL REQGVEEHETLLLRRKFFYS DQNVDSRDPVQLNLLYVQAR |
| Tissue Specificity | Isoform 2: Expressed at low to non-detectable levels in many tissues but highly expressed in skin and pancreas with other tissues including kidney cortex, endocervix, testis, pituitary, liver, and spleen also showing robust expression. |
| Function | High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. |
| Protein Name | Talin-1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-381038Reactome: R-HSA-399955Reactome: R-HSA-445355Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | Cell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell SurfaceCell JunctionFocal AdhesionColocalizes With Layn At The Membrane RufflesLocalized Preferentially In Focal Adhesions Than Fibrillar Adhesions |
| Alternative Antibody Names | Anti-Talin-1 antibodyAnti-TLN1 antibodyAnti-KIAA1027 antibodyAnti-TLN antibody |
Information sourced from Uniprot.org
