Anti-TINF2 antibody (71-120 aa) (STJ96027)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TINF2 at the amino acid range 71-120
General Information
| Short Description | Rabbit polyclonal anti-TERF1-interacting nuclear factor 2 (71-120 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TINF2 |
| Gene ID | 26277 |
| Uniprot ID | TINF2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TINF2 at the amino acid range 71-120 |
| Immunogen Region | 71-120 aa |
| Specificity | TIN2 Polyclonal Antibody detects endogenous levels of TIN2 protein. |
Additional Info
| Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends.without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. |
| Protein Name | Terf1-Interacting Nuclear Factor 2Trf1-Interacting Nuclear Protein 2 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-1221632Reactome: R-HSA-171306Reactome: R-HSA-171319Reactome: R-HSA-174411Reactome: R-HSA-174414Reactome: R-HSA-174417Reactome: R-HSA-174430Reactome: R-HSA-174437Reactome: R-HSA-2559586Reactome: R-HSA-9670095 |
| Cellular Localisation | NucleusChromosomeTelomereAssociated With TelomeresIsoform 1: Nucleus Matrix |
| Alternative Antibody Names | Anti-Terf1-Interacting Nuclear Factor 2 antibodyAnti-Trf1-Interacting Nuclear Protein 2 antibodyAnti-TINF2 antibodyAnti-TIN2 antibody |
Information sourced from Uniprot.org