Host: | Rabbit |
Applications: | WB/IHC/IF/ELISA |
Reactivity: | Human/Rat/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-TERF1-interacting nuclear factor 2 (71-120 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | TINF2 |
Gene ID: | 26277 |
Uniprot ID: | TINF2_HUMAN |
Immunogen Region: | 71-120 aa |
Specificity: | TIN2 Polyclonal Antibody detects endogenous levels of TIN2 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human TINF2 at the amino acid range 71-120 |
Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends.without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. |
Protein Name | Terf1-Interacting Nuclear Factor 2Trf1-Interacting Nuclear Protein 2 |
Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-1221632Reactome: R-HSA-171306Reactome: R-HSA-171319Reactome: R-HSA-174411Reactome: R-HSA-174414Reactome: R-HSA-174417Reactome: R-HSA-174430Reactome: R-HSA-174437Reactome: R-HSA-2559586Reactome: R-HSA-9670095 |
Cellular Localisation | NucleusChromosomeTelomereAssociated With TelomeresIsoform 1: Nucleus Matrix |
Alternative Antibody Names | Anti-Terf1-Interacting Nuclear Factor 2 antibodyAnti-Trf1-Interacting Nuclear Protein 2 antibodyAnti-TINF2 antibodyAnti-TIN2 antibody |
Information sourced from Uniprot.org