• Western blot analysis of extracts of various cell lines, using TIN2/TINF2 rabbit monoclonal antibody (STJ11102539) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
  • Western blot analysis of extracts of various cell lines, using TIN2/TINF2 Rabbit monoclonal antibody (STJ11102539) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-TINF2 antibody (210-309) [S9MR] (STJ11102539)

SKU:
STJ11102539

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Tin2 (210-309) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S9MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TINF2
Gene ID: 26277
Uniprot ID: TINF2_HUMAN
Immunogen Region: 210-309
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 210-309 of human TIN2/TINF2 (Q9BSI4).
Immunogen Sequence: NLAEPMEQNPPQQQRLALHN PLPKAKPGTHLPQGPSSRTH PEPLAGRHFNLAPLGRRRVQ SQWASTRGGHKERPTVMLFP FRNLGSPTQVISKPESKEEH
Tissue Specificity Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Function Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends.without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
Protein Name Terf1-Interacting Nuclear Factor 2
Trf1-Interacting Nuclear Protein 2
Database Links Reactome: R-HSA-110328
Reactome: R-HSA-110329
Reactome: R-HSA-110330
Reactome: R-HSA-110331
Reactome: R-HSA-1221632
Reactome: R-HSA-171306
Reactome: R-HSA-171319
Reactome: R-HSA-174411
Reactome: R-HSA-174414
Reactome: R-HSA-174417
Reactome: R-HSA-174430
Reactome: R-HSA-174437
Reactome: R-HSA-2559586
Reactome: R-HSA-9670095
Cellular Localisation Nucleus
Chromosome
Telomere
Associated With Telomeres
Isoform 1: Nucleus Matrix
Alternative Antibody Names Anti-Terf1-Interacting Nuclear Factor 2 antibody
Anti-Trf1-Interacting Nuclear Protein 2 antibody
Anti-TINF2 antibody
Anti-TIN2 antibody

Information sourced from Uniprot.org

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