Anti-TIMP2 antibody (120-220 aa) [S1MR] (STJ11103441)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal TIMP2 (120-220 aa) antibody for use in WB and ELISA in human, mouse, rat and african green monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/African green monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S1MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TIMP2 |
| Gene ID | 7077 |
| Uniprot ID | TIMP2_HUMAN |
| Immunogen Region | 120-220 aa |
| Immunogen Sequence | GKMHITLCDFIVPWDTLSTT QKKSLNHRYQMGCECKITRC PMIPCYISSPDECLWMDWVT EKNINGHQAKFFACIKRSDG SCAWYRGAAPPKQEFLDIED P |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 120-220 of human TIMP2. (NP_003246.1). |
Additional Info
| Post Translational Modifications | The activity of TIMP2 is dependent on the presence of disulfide bonds. |
| Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. |
| Protein Name | Metalloproteinase Inhibitor 2Csc-21kTissue Inhibitor Of Metalloproteinases 2Timp-2 |
| Database Links | Reactome: R-HSA-1592389Reactome: R-HSA-6798695Reactome: R-HSA-9839383 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Metalloproteinase Inhibitor 2 antibodyAnti-Csc-21k antibodyAnti-Tissue Inhibitor Of Metalloproteinases 2 antibodyAnti-Timp-2 antibodyAnti-TIMP2 antibody |
Information sourced from Uniprot.org