| Host: |
Mouse |
| Applications: |
IHC/IF/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Metalloproteinase inhibitor 1 (50-150 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
PT2236 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1k |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: |
WB 500-2000IHC-P 1:100-500IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TIMP1 |
| Gene ID: |
7076 |
| Uniprot ID: |
TIMP1_HUMAN |
| Immunogen Region: |
50-150 aa |
| Specificity: |
This antibody detects endogenous levels of human Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of m |
| Immunogen: |
Synthesized peptide derived from the human Tissue Inhibitor of Metalloproteinases 1 (TIMP1) at the amino acid range 50-150 |
| Post Translational Modifications | The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated. |
| Function | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro.but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. |
| Protein Name | Metalloproteinase Inhibitor 1Erythroid-Potentiating ActivityEpaFibroblast Collagenase InhibitorCollagenase InhibitorTissue Inhibitor Of Metalloproteinases 1Timp-1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1592389Reactome: R-HSA-381426Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Metalloproteinase Inhibitor 1 antibodyAnti-Erythroid-Potentiating Activity antibodyAnti-Epa antibodyAnti-Fibroblast Collagenase Inhibitor antibodyAnti-Collagenase Inhibitor antibodyAnti-Tissue Inhibitor Of Metalloproteinases 1 antibodyAnti-Timp-1 antibodyAnti-TIMP1 antibodyAnti-CLGI antibodyAnti-TIMP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
