Anti-THEMIS2 antibody (1-260) (STJ117550)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal THEMIS2 (1-260) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | THEMIS2 |
| Gene ID | 9473 |
| Uniprot ID | THMS2_HUMAN |
| Immunogen Region | 1-260 |
| Immunogen Sequence | MEPVPLQDFVRALDPASLPR VLRVCSGVYFEGSIYEISGN ECCLSTGDLIKVTQVRLQKV VCENPKTSQTMELAPNFQGY FTPLNTPQSYETLEELVSAT TQSSKQLPTCFMSTHRIVTE GRVVTEDQLLMLEAVVMHLG IRSARCVLGMEGQQVILHLP LSQKGPFWTWEPSAPRTLLQ VLQDPALKDLVLTCPTLPWH SLILRPQYEIQAIMHIFSSL RIAATRSAAQTQGEDLARV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human THEMIS2 (NP_004839.2). |
Additional Info
| Tissue Specificity | Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1. |
| Post Translational Modifications | Phosphorylation at Tyr-632 is induced by LPS. Phosphorylated by Src kinases (Lck or Fyn) following BCR engagement. |
| Function | May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways. |
| Protein Name | Protein Themis2Induced By Contact To Basement Membrane 1 ProteinProtein Icb-1Thymocyte-Expressed Molecule Involved In Selection Protein 2 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Protein Themis2 antibodyAnti-Induced By Contact To Basement Membrane 1 Protein antibodyAnti-Protein Icb-1 antibodyAnti-Thymocyte-Expressed Molecule Involved In Selection Protein 2 antibodyAnti-THEMIS2 antibodyAnti-C1orf38 antibodyAnti-ICB1 antibody |
Information sourced from Uniprot.org