| Host: | Rabbit |
| Applications: | IHC |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-TFDP1 (1-290) is suitable for use in Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TFDP1 |
| Gene ID: | 7027 |
| Uniprot ID: | TFDP1_HUMAN |
| Immunogen Region: | 1-290 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human DP1/DP1/TFDP1 (NP_009042.1). |
| Immunogen Sequence: | MAKDAGLIEANGELKVFIDQ NLSPGKGVVSLVAVHPSTVN PLGKQLLPKTFGQSNVNIAQ QVVIGTPQRPAASNTLVVGS PHTPSTHFASQNQPSDSSPW SAGKRNRKGEKNGKGLRHFS MKVCEKVQRKGTTSYNEVAD ELVAEFSAADNHILPNESAY DQKNIRRRVYDALNVLMAMN IISKEKKEIKWIGLPTNSAQ ECQNLEVERQRRLERIKQKQ SQLQELILQQIAFKNLVQR |
| Tissue Specificity | Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart. |
| Post Translational Modifications | Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation. Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation. |
| Function | Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTCCGCGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters. |
| Protein Name | Transcription Factor Dp-1Drtf1-Polypeptide 1Drtf1E2f Dimerization Partner 1 |
| Database Links | Reactome: R-HSA-111448Reactome: R-HSA-113501Reactome: R-HSA-1362277Reactome: R-HSA-1362300Reactome: R-HSA-139915Reactome: R-HSA-1538133Reactome: R-HSA-1912408Reactome: R-HSA-2173796Reactome: R-HSA-2559580Reactome: R-HSA-2559585Reactome: R-HSA-6804114Reactome: R-HSA-69202Reactome: R-HSA-69205Reactome: R-HSA-69231Reactome: R-HSA-69656Reactome: R-HSA-8953750Reactome: R-HSA-9616222Reactome: R-HSA-9661069 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Cytoplasm And Nucleus And Translocates Into The Nuclear Compartment Upon Heterodimerization With E2f1 |
| Alternative Antibody Names | Anti-Transcription Factor Dp-1 antibodyAnti-Drtf1-Polypeptide 1 antibodyAnti-Drtf1 antibodyAnti-E2f Dimerization Partner 1 antibodyAnti-TFDP1 antibodyAnti-DP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
