| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TFB1M (28-346) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TFB1M |
| Gene ID: |
51106 |
| Uniprot ID: |
TFB1M_HUMAN |
| Immunogen Region: |
28-346 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 28-346 of human TFB1M (NP_057104.2). |
| Immunogen Sequence: |
QAAKQLSQNFLLDLRLTDKI VRKAGNLTNAYVYEVGPGPG GITRSILNADVAELLVVEKD TRFIPGLQMLSDAAPGKLRI VHGDVLTFKVEKAFSESLKR PWEDDPPNVHIIGNLPFSVS TPLIIKWLENISCRDGPFVY GRTQMTLTFQKEVAERLAAN TGSKQRSRLSVMAQYLCNVR HIFTIPGQAFVPKPEVDVGV VHFTPLIQPKIEQPFKLVEK VVQNVFQFRRKYCHRGLRM |
| Tissue Specificity | Ubiquitously expressed. |
| Function | S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. |
| Protein Name | Dimethyladenosine Transferase 1 - MitochondrialMitochondrial 12s Rrna Dimethylase 1Mitochondrial Transcription Factor B1H-MttfbH-Mttfb1Htfb1mMttfb1S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 1 |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-6793080 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Dimethyladenosine Transferase 1 - Mitochondrial antibodyAnti-Mitochondrial 12s Rrna Dimethylase 1 antibodyAnti-Mitochondrial Transcription Factor B1 antibodyAnti-H-Mttfb antibodyAnti-H-Mttfb1 antibodyAnti-Htfb1m antibodyAnti-Mttfb1 antibodyAnti-S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 1 antibodyAnti-TFB1M antibodyAnti-CGI-75 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and CDK7 knockout (KO) 293T cells, using [KO Validated] CDK7 Rabbit polyclonal antibody (STJ114808) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/93895/375110/STJ114808_1__03809.1713141794.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and CDK7 knockout (KO) 293T cells, using [KO Validated] CDK7 Rabbit polyclonal antibody (STJ114808) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.")