| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TFB1M |
| Gene ID: |
51106 |
| Uniprot ID: |
TFB1M_HUMAN |
| Immunogen Region: |
28-346 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 28-346 of human TFB1M (NP_057104.2). |
| Immunogen Sequence: |
QAAKQLSQNFLLDLRLTDKI VRKAGNLTNAYVYEVGPGPG GITRSILNADVAELLVVEKD TRFIPGLQMLSDAAPGKLRI VHGDVLTFKVEKAFSESLKR PWEDDPPNVHIIGNLPFSVS TPLIIKWLENISCRDGPFVY GRTQMTLTFQKEVAERLAAN TGSKQRSRLSVMAQYLCNVR HIFTIPGQAFVPKPEVDVGV VHFTPLIQPKIEQPFKLVEK VVQNVFQFRRKYCHRGLRM |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1583 and A1584) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. |
| Protein Name | Dimethyladenosine Transferase 1 - MitochondrialMitochondrial 12s Rrna Dimethylase 1Mitochondrial Transcription Factor B1H-MttfbH-Mttfb1Htfb1mMttfb1S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 1 |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-6793080 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Dimethyladenosine Transferase 1 - Mitochondrial antibodyAnti-Mitochondrial 12s Rrna Dimethylase 1 antibodyAnti-Mitochondrial Transcription Factor B1 antibodyAnti-H-Mttfb antibodyAnti-H-Mttfb1 antibodyAnti-Htfb1m antibodyAnti-Mttfb1 antibodyAnti-S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 1 antibodyAnti-TFB1M antibodyAnti-CGI-75 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
