Anti-TFAP2B antibody (1-100) (STJ110244)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TFAP2B (1-100) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TFAP2B |
| Gene ID | 7021 |
| Uniprot ID | AP2B_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MHSPPRDQAAIMLWKLVENV KYEDIYEDRHDGVPSHSSRL SQLGSVSQGPYSSAPPLSHT PSSDFQPPYFPPPYQPLPYH QSQDPYSHVNDPYSLNPLHQ |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TFAP2B (Q92481). |
Additional Info
| Post Translational Modifications | Sumoylated on Lys-21.which inhibits transcriptional activity. |
| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. |
| Protein Name | Transcription Factor Ap-2-BetaAp2-BetaActivating Enhancer-Binding Protein 2-Beta |
| Database Links | Reactome: R-HSA-3232118Reactome: R-HSA-8866904Reactome: R-HSA-8866907Reactome: R-HSA-8866910Reactome: R-HSA-9834899 |
| Cellular Localisation | NucleusIn The BrainLocalizes To The Arcuate Hypothalamic NucleusThe Ventromedial Hypothalamic Nucleus And The Accumbens Nucleus Of The Ventral Striatum |
| Alternative Antibody Names | Anti-Transcription Factor Ap-2-Beta antibodyAnti-Ap2-Beta antibodyAnti-Activating Enhancer-Binding Protein 2-Beta antibodyAnti-TFAP2B antibody |
Information sourced from Uniprot.org