| Post Translational Modifications | Sumoylated on Lys-21.which inhibits transcriptional activity. |
| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. |
| Protein Name | Transcription Factor Ap-2-BetaAp2-BetaActivating Enhancer-Binding Protein 2-Beta |
| Database Links | Reactome: R-HSA-3232118Reactome: R-HSA-8866904Reactome: R-HSA-8866907Reactome: R-HSA-8866910Reactome: R-HSA-9834899 |
| Cellular Localisation | NucleusIn The BrainLocalizes To The Arcuate Hypothalamic NucleusThe Ventromedial Hypothalamic Nucleus And The Accumbens Nucleus Of The Ventral Striatum |
| Alternative Antibody Names | Anti-Transcription Factor Ap-2-Beta antibodyAnti-Ap2-Beta antibodyAnti-Activating Enhancer-Binding Protein 2-Beta antibodyAnti-TFAP2B antibody |
Information sourced from Uniprot.org
