Anti-TCP1 antibody (307-556) (STJ115327)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TCP1 (307-556) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TCP1 |
| Gene ID | 6950 |
| Uniprot ID | TCPA_HUMAN |
| Immunogen Region | 307-556 |
| Immunogen Sequence | AVRRVLKRDLKRIAKASGAT ILSTLANLEGEETFEAAMLG QAEEVVQERICDDELILIKN TKARTSASIILRGANDFMCD EMERSLHDALCVVKRVLESK SVVPGGGAVEAALSIYLENY ATSMGSREQLAIAEFARSLL VIPNTLAVNAAQDSTDLVAK LRAFHNEAQVNPERKNLKWI GLDLSNGKPRDNKQAGVFEP TIVKVKSLKFATEAAITILR IDDLIKLHPESKDDKHGSY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 307-556 of human TCP1 (NP_110379.2). |
Additional Info
| Function | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. |
| Protein Name | T-Complex Protein 1 Subunit AlphaTcp-1-AlphaCct-AlphaChaperonin Containing T-Complex Polypeptide 1 Subunit 1 |
| Database Links | Reactome: R-HSA-389957Reactome: R-HSA-389960Reactome: R-HSA-390450Reactome: R-HSA-390471Reactome: R-HSA-5620922Reactome: R-HSA-6814122Reactome: R-HSA-8950505 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Antibody Names | Anti-T-Complex Protein 1 Subunit Alpha antibodyAnti-Tcp-1-Alpha antibodyAnti-Cct-Alpha antibodyAnti-Chaperonin Containing T-Complex Polypeptide 1 Subunit 1 antibodyAnti-TCP1 antibodyAnti-CCT1 antibodyAnti-CCTA antibody |
Information sourced from Uniprot.org