• STJ70119 (4µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.

Anti-TBL1X/TBL1XR1 antibody (C-Term) (STJ70119)

SKU:
STJ70119-100

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Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human/Mouse/Rat/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-TBL1X/TBL1XR1 (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-Recommended concentration, 4-6µg/ml
ELISA-antibody detection limit dilution 1:4000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: TBL1X
Gene ID: 6907
Uniprot ID: TBL1X_HUMAN
Immunogen Region: C-Term
Accession Number: NP_005638.1; NP_001132938.1; NP_001132939.1; NP_001132940.1; NP_078941.2
Specificity: This antibody is also expected to recognise the human protein TBLR1 (NP_078941) , which is very similar. Variants (NP_005638.1; NP_001132938.1) encode isoform a (TBL1X) and variants (NP_001132939.1; NP_001132940.1 ) encode isoform b (TBLX1).
Immunogen Sequence: SASDGSVCVLDLRK
Function F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
Protein Name F-Box-Like/Wd Repeat-Containing Protein Tbl1x
Smap55
Transducin Beta-Like Protein 1x
Transducin-Beta-Like Protein 1 - X-Linked
Database Links Reactome: R-HSA-1368082
Reactome: R-HSA-1368108
Reactome: R-HSA-1989781
Reactome: R-HSA-2122947
Reactome: R-HSA-2151201
Reactome: R-HSA-2426168
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-3214815
Reactome: R-HSA-350054
Reactome: R-HSA-381340
Reactome: R-HSA-400206
Reactome: R-HSA-400253
Reactome: R-HSA-9022537
Reactome: R-HSA-9022692
Reactome: R-HSA-9029569
Reactome: R-HSA-9609690
Reactome: R-HSA-9707564
Reactome: R-HSA-9707616
Cellular Localisation Nucleus
Colocalized With Mecp2 To The Heterochromatin Foci
Alternative Antibody Names Anti-F-Box-Like/Wd Repeat-Containing Protein Tbl1x antibody
Anti-Smap55 antibody
Anti-Transducin Beta-Like Protein 1x antibody
Anti-Transducin-Beta-Like Protein 1 - X-Linked antibody
Anti-TBL1X antibody
Anti-TBL1 antibody

Information sourced from Uniprot.org

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