Anti-TBCB antibody (STJ191559)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Tubulin-folding cofactor B for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TBCB |
| Gene ID | 1155 |
| Uniprot ID | TBCB_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | TBCB Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylation by PAK1 is required for normal function. Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome. (Microbial infection) Glycosylated residues by S.typhimurium protein Ssek1: arginine GlcNAcylation promotes microtubule stability. |
| Function | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. |
| Protein Name | Tubulin-Folding Cofactor BCytoskeleton-Associated Protein 1Cytoskeleton-Associated Protein CkapiTubulin-Specific Chaperone B |
| Database Links | Reactome: R-HSA-389977 |
| Cellular Localisation | CytoplasmCytoskeletonColocalizes With MicrotubulesIn Differentiated NeuronsLocated In The CytoplasmIn Differentiating NeuronsAccumulates At The Growth Cone |
| Alternative Antibody Names | Anti-Tubulin-Folding Cofactor B antibodyAnti-Cytoskeleton-Associated Protein 1 antibodyAnti-Cytoskeleton-Associated Protein Ckapi antibodyAnti-Tubulin-Specific Chaperone B antibodyAnti-TBCB antibodyAnti-CG22 antibodyAnti-CKAP1 antibody |
Information sourced from Uniprot.org