| Short Description : | Rabbit monoclonal TACC3 (1-100) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TACC3 |
| Gene ID: | 10460 |
| Uniprot ID: | TACC3_HUMAN |
| Immunogen Region: | 1-100 |
| Immunogen Sequence: | MSLQVLNDKNVSNEKNTENC DFLFSPPEVTGRSSVLRVSQ KENVPPKNLAKAMKVTFQTP LRDPQTHRILSPSMASKLEA PFTQDDTLGLENSHPVWTQK |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TACC3 (NP_006333.1). |
| Function | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell growth and differentiation. May contribute to cancer. |
| Protein Name | Transforming Acidic Coiled-Coil-Containing Protein 3Eric-1 |
| Database Links | Reactome: R-HSA-9013507Reactome: R-HSA-9604323 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleSpindle PoleIn Complex With Ckap5 Localized To Microtubule Plus-Ends In Mitosis And InterphaseIn Complex With Ckap5 And Clathrin Localized To Inter-Microtubule Bridges In Mitotic Spindles |
| Alternative Antibody Names | Anti-Transforming Acidic Coiled-Coil-Containing Protein 3 antibodyAnti-Eric-1 antibodyAnti-TACC3 antibodyAnti-ERIC1 antibody |
Information sourced from Uniprot.org
