Anti-SYMPK antibody (310-530) (STJ111388)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SYMPK (310-530) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SYMPK |
| Gene ID | 8189 |
| Uniprot ID | SYMPK_HUMAN |
| Immunogen Region | 310-530 |
| Immunogen Sequence | KHPASLEFQAQITTLLVDLG TPQAEIARNMPSSKDTRKRP RDDSDSTLKKMKLEPNLGED DEDKDLEPGPSGTSKASAQI SGQSDTDITAEFLQPLLTPD NVANLVLISMVYLPEAMPAS FQAIYTPVESAGTEAQIKHL ARLMATQMTAAGLGPGVEQT KQCKEEPKEEKVVKTESVLI KRRLSAQGQAISVVGSLSSM SPLEEEAPQAKRRPEPIIPV T |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 310-530 of human SYMPK (NP_004810.2). |
Additional Info
| Tissue Specificity | In testis, expressed in polar epithelia and Sertoli cells but not in vascular endothelia. The protein is detected in stomach, duodenum, pancreas, liver, fetal brain, carcinomas, lens-forming cells, fibroblasts, lymphocytes, lymphoma cells, erythroleukemia cells but not in endothelium of vessels, epidermis, intercalated disks, Purkinje fiber cells of the heart and lymph node. |
| Function | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. |
| Protein Name | Symplekin |
| Database Links | Reactome: R-HSA-159231Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595 |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionTight JunctionCell MembranePeripheral Membrane ProteinCytoplasmic SideNucleusNucleoplasmCytoplasmic Face Of Adhesion Plaques (Major) And Nucleoplasm (Minor) (In Cells With Tj)Nucleoplasm (In Cells Without Tj)Nuclear Bodies Of Heat-Stressed CellsColocalizes With Hsf1 In Nuclear Stress Bodies Upon Heat Shock |
| Alternative Antibody Names | Anti-Symplekin antibodyAnti-SYMPK antibodyAnti-SPK antibody |
Information sourced from Uniprot.org