| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SYMPK (310-530) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SYMPK |
| Gene ID: |
8189 |
| Uniprot ID: |
SYMPK_HUMAN |
| Immunogen Region: |
310-530 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 310-530 of human SYMPK (NP_004810.2). |
| Immunogen Sequence: |
KHPASLEFQAQITTLLVDLG TPQAEIARNMPSSKDTRKRP RDDSDSTLKKMKLEPNLGED DEDKDLEPGPSGTSKASAQI SGQSDTDITAEFLQPLLTPD NVANLVLISMVYLPEAMPAS FQAIYTPVESAGTEAQIKHL ARLMATQMTAAGLGPGVEQT KQCKEEPKEEKVVKTESVLI KRRLSAQGQAISVVGSLSSM SPLEEEAPQAKRRPEPIIPV T |
| Tissue Specificity | In testis, expressed in polar epithelia and Sertoli cells but not in vascular endothelia. The protein is detected in stomach, duodenum, pancreas, liver, fetal brain, carcinomas, lens-forming cells, fibroblasts, lymphocytes, lymphoma cells, erythroleukemia cells but not in endothelium of vessels, epidermis, intercalated disks, Purkinje fiber cells of the heart and lymph node. |
| Function | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. |
| Protein Name | Symplekin |
| Database Links | Reactome: R-HSA-159231Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595 |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionTight JunctionCell MembranePeripheral Membrane ProteinCytoplasmic SideNucleusNucleoplasmCytoplasmic Face Of Adhesion Plaques (Major) And Nucleoplasm (Minor) (In Cells With Tj)Nucleoplasm (In Cells Without Tj)Nuclear Bodies Of Heat-Stressed CellsColocalizes With Hsf1 In Nuclear Stress Bodies Upon Heat Shock |
| Alternative Antibody Names | Anti-Symplekin antibodyAnti-SYMPK antibodyAnti-SPK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
