Anti-SYCP3 antibody (Internal) (STJ96482)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the Internal region of human SCP-3.
General Information
| Short Description | Rabbit polyclonal anti-Synaptonemal complex protein 3 (Internal) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SYCP3 |
| Gene ID | 50511 |
| Uniprot ID | SYCP3_HUMAN |
| Immunogen | Synthesized peptide derived from the Internal region of human SCP-3. |
| Immunogen Region | Internal |
| Specificity | SCP-3 Polyclonal Antibody detects endogenous levels of SCP-3 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated. |
| Function | Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2. |
| Protein Name | Synaptonemal Complex Protein 3Scp-3 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | NucleusChromosomeCentromereIt Is Present In Early Unpaired CoresIn The Lateral Domains Of The Synaptonemal Complex And In The Chromosome Cores When They Separate At DiploteneIt Is Found Axial To The Metaphase I Chromosomes And In Association With Pairs Of Sister CentromeresThe Centromere-Associated Protein Becomes Dissociated From The Centromeres At Anaphase Ii And Is Not Found In Mitotic Metaphase Centromeres |
| Alternative Antibody Names | Anti-Synaptonemal Complex Protein 3 antibodyAnti-Scp-3 antibodyAnti-SYCP3 antibodyAnti-SCP3 antibody |
Information sourced from Uniprot.org