Anti-SV2B antibody (415-540) (STJ118704)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SV2B (415-540) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SV2B |
| Gene ID | 9899 |
| Uniprot ID | SV2B_HUMAN |
| Immunogen Region | 415-540 |
| Immunogen Sequence | IRYFQDEEYKSKMKVFFGEH VYGATINFTMENQIHQHGKL VNDKFTRMYFKHVLFEDTFF DECYFEDVTSTDTYFKNCTI ESTIFYNTDLYEHKFINCRF INSTFLEQKEGCHMDLEQDN DFLIYL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 415-540 of human SV2B (NP_055663.1). |
Additional Info
| Post Translational Modifications | N-glycosylated. The N-terminal cytoplasmic domain is phosphorylated by CK1. |
| Function | Probably plays a role in the control of regulated secretion in neural and endocrine cells. (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA).glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. |
| Protein Name | Synaptic Vesicle Glycoprotein 2b |
| Database Links | Reactome: R-HSA-5250955Reactome: R-HSA-5250968Reactome: R-HSA-5250981Reactome: R-HSA-5250992 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinAcrosomeAssociated With Synaptic-Like Microvesicles But Not With Insulin-Containing Vesicles In Insulin-Secreting Cells Of The PancreasLocalizes To Microvesicles In The PinealocytesLocalizes To The Acrosome In Spermatids |
| Alternative Antibody Names | Anti-Synaptic Vesicle Glycoprotein 2b antibodyAnti-SV2B antibodyAnti-KIAA0735 antibody |
Information sourced from Uniprot.org