Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-SV2B (415-540) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
SV2B |
Gene ID: |
9899 |
Uniprot ID: |
SV2B_HUMAN |
Immunogen Region: |
415-540 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 415-540 of human SV2B (NP_055663.1). |
Immunogen Sequence: |
IRYFQDEEYKSKMKVFFGEH VYGATINFTMENQIHQHGKL VNDKFTRMYFKHVLFEDTFF DECYFEDVTSTDTYFKNCTI ESTIFYNTDLYEHKFINCRF INSTFLEQKEGCHMDLEQDN DFLIYL |
Post Translational Modifications | N-glycosylated. The N-terminal cytoplasmic domain is phosphorylated by CK1. |
Function | Probably plays a role in the control of regulated secretion in neural and endocrine cells. (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA).glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. |
Protein Name | Synaptic Vesicle Glycoprotein 2b |
Database Links | Reactome: R-HSA-5250955Reactome: R-HSA-5250968Reactome: R-HSA-5250981Reactome: R-HSA-5250992 |
Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinAcrosomeAssociated With Synaptic-Like Microvesicles But Not With Insulin-Containing Vesicles In Insulin-Secreting Cells Of The PancreasLocalizes To Microvesicles In The PinealocytesLocalizes To The Acrosome In Spermatids |
Alternative Antibody Names | Anti-Synaptic Vesicle Glycoprotein 2b antibodyAnti-SV2B antibodyAnti-KIAA0735 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance