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Anti-surfactant-A antibody [SM0512] (STJA0010512)

Immunohistochemistry analysis of surfactant-A. Sample: Human Lung squamous cell carcinoma, 4% PFA 12-24h. Antigen retrieval: Citrate buffer, pressure cooker 2min. Primary antibody: 1:1000, 4C overnight. Secondary antibody: HRP Goat Anti-mouse lgG, 1:200, RT, 1h.
Immunohistochemistry analysis of surfactant-A. Sample: Human lung adenocarcinoma, 4% PFA 12-24h. Antigen retrieval: Citrate buffer, pressure cooker 2min. Primary antibody: 1:1000, 4C overnight. Secondary antibody: HRP Goat Anti-mouse lgG, 1:200, RT, 1h.

Anti-surfactant-A antibody [SM0512] (STJA0010512)

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STJA0010512

£170.50 - £233.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Mouse
Applications:	IHC/IF
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-surfactant-A is suitable for use in Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	SM0512
Conjugation:	Unconjugated
Isotype:	IgG2bk
Formulation:	PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol.
Purification:	Affinity purification
Dilution Range:	IHC/IF (H) 1:500-1500
Storage Instruction:	Store at-20C for up to one year, and avoid repeated freeze-thaw cycles.

Gene Symbol:	SFTPA1
Gene ID:	653509
Uniprot ID:	SFTA1_HUMAN
Immunogen:	Recombinant protein corresponding to Human surfactant-A

Function	In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages. (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen. When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen.
Protein Name	Pulmonary Surfactant-Associated Protein A1 Psp-A Pspa Sp-A Sp-A1 35 Kda Pulmonary Surfactant-Associated Protein Alveolar Proteinosis Protein Collectin-4
Database Links	Reactome: R-HSA-166016 Reactome: R-HSA-168179 Reactome: R-HSA-391160 Reactome: R-HSA-5683826 Reactome: R-HSA-5686938 Reactome: R-HSA-5688849 Reactome: R-HSA-5688890
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix Surface Film
Alternative Antibody Names	Anti-Pulmonary Surfactant-Associated Protein A1 antibody Anti-Psp-A antibody Anti-Pspa antibody Anti-Sp-A antibody Anti-Sp-A1 antibody Anti-35 Kda Pulmonary Surfactant-Associated Protein antibody Anti-Alveolar Proteinosis Protein antibody Anti-Collectin-4 antibody Anti-SFTPA1 antibody Anti-COLEC4 antibody Anti-PSAP antibody Anti-SFTP1 antibody Anti-SFTPA antibody Anti-SFTPA1B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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