Anti-surfactant-A antibody [SM0512] (STJA0010512)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant protein corresponding to Human surfactant-A
General Information
| Short Description | Mouse monoclonal anti-surfactant-A for use in IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM0512 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | IHC/IF (H) 1:500-1500 |
| Formulation | PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | SFTPA1 |
| Gene ID | 653509 |
| Uniprot ID | SFTA1_HUMAN |
| Immunogen | Recombinant protein corresponding to Human surfactant-A |
Additional Info
| Function | In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages. (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen. When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. |
| Protein Name | Pulmonary Surfactant-Associated Protein A1Psp-APspaSp-ASp-A135 Kda Pulmonary Surfactant-Associated ProteinAlveolar Proteinosis ProteinCollectin-4 |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-168179Reactome: R-HSA-391160Reactome: R-HSA-5683826Reactome: R-HSA-5686938Reactome: R-HSA-5688849Reactome: R-HSA-5688890 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixSurface Film |
| Alternative Antibody Names | Anti-Pulmonary Surfactant-Associated Protein A1 antibodyAnti-Psp-A antibodyAnti-Pspa antibodyAnti-Sp-A antibodyAnti-Sp-A1 antibodyAnti-35 Kda Pulmonary Surfactant-Associated Protein antibodyAnti-Alveolar Proteinosis Protein antibodyAnti-Collectin-4 antibodyAnti-SFTPA1 antibodyAnti-COLEC4 antibodyAnti-PSAP antibodyAnti-SFTP1 antibodyAnti-SFTPA antibodyAnti-SFTPA1B antibody |
Information sourced from Uniprot.org