Anti-SUPV3L1 antibody (577-786) (STJ111992)

Name: Anti-SUPV3L1 antibody (577-786) (STJ111992)
SKU: STJ111992
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ111992

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Short Description	Rabbit polyclonal SUPV3L1 (577-786) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:1000-1:4000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	SUPV3L1
Gene ID	6832
Uniprot ID	SUV3_HUMAN
Immunogen Region	577-786
Immunogen Sequence	APINKKQPFVCSSLLQFARQ YSRNEPLTFAWLRRYIKWPL LPPKNIKDLMDLEAVHDVLD LYLWLSYRFMDMFPDASLIR DLQKELDGIIQDGVHNITKL IKMSETHKLLNLEGFPSGSQ SRLSGTLKSQARRTRGTKAL GSKATEPPSPDAGELSLASR LVQQGLLTPDMLKQLEKEWM TQQTEHNKEKTESGTHPKGT RRKKKEPDSD
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 577-786 of human SUPV3L1 (NP_003162.2).

Tissue Specificity	Broadly expressed.
Function	Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria.regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
Protein Name	Atp-Dependent Rna Helicase Supv3l1 - Mitochondrial Suppressor Of Var1 3-Like Protein 1 Suv3-Like Protein 1
Database Links	Reactome: R-HSA-9836573
Cellular Localisation	Nucleus Mitochondrion Matrix Mitochondrion Nucleoid
Alternative Antibody Names	Anti-Atp-Dependent Rna Helicase Supv3l1 - Mitochondrial antibody Anti-Suppressor Of Var1 3-Like Protein 1 antibody Anti-Suv3-Like Protein 1 antibody Anti-SUPV3L1 antibody Anti-SUV3 antibody

Information sourced from Uniprot.org