Anti-STK38 antibody (418-465) (STJ110490)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal STK38 (418-465) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STK38 |
| Gene ID | 11329 |
| Uniprot ID | STK38_HUMAN |
| Immunogen Region | 418-465 |
| Immunogen Sequence | HRIGAPGVEEIKSNSFFEGV DWEHIRERPAAISIEIKSID DTSNFDEFPESDILKPTVAT SNHPETDYKNKDWVFINYTY KRFEGLTARGAIPSYMKAAK |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 366-465 of human STK38 (NP_009202.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. |
| Post Translational Modifications | ISGylated. Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B. |
| Function | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation. |
| Protein Name | Serine/Threonine-Protein Kinase 38Ndr1 Protein KinaseNuclear Dbf2-Related Kinase 1 |
| Database Links | Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | NucleusCytoplasmChromosomeLocalizes To Dna Double-Strand Breaks In Response To Dna Damage |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase 38 antibodyAnti-Ndr1 Protein Kinase antibodyAnti-Nuclear Dbf2-Related Kinase 1 antibodyAnti-STK38 antibodyAnti-NDR1 antibody |
Information sourced from Uniprot.org