Western blot analysis of various lysates, using STK38 rabbit polyclonal antibody (STJ110490) at 1:800 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-STK38 antibody (418-465) (STJ110490)

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STJ110490
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: STK38
Gene ID: 11329
Uniprot ID: STK38_HUMAN
Immunogen Region: 418-465
Specificity: A synthetic peptide corresponding to a sequence within amino acids 366-465 of human STK38 (NP_009202.1).
Immunogen Sequence: HRIGAPGVEEIKSNSFFEGV DWEHIRERPAAISIEIKSID DTSNFDEFPESDILKPTVAT SNHPETDYKNKDWVFINYTY KRFEGLTARGAIPSYMKAAK
Tissue Specificity Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
Post Translational Modifications ISGylated. Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B.
Function Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation.
Protein Name Serine/Threonine-Protein Kinase 38
Ndr1 Protein Kinase
Nuclear Dbf2-Related Kinase 1
Database Links Reactome: R-HSA-9013418
Reactome: R-HSA-9013422
Cellular Localisation Nucleus
Cytoplasm
Chromosome
Localizes To Dna Double-Strand Breaks In Response To Dna Damage
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase 38 antibody
Anti-Ndr1 Protein Kinase antibody
Anti-Nuclear Dbf2-Related Kinase 1 antibody
Anti-STK38 antibody
Anti-NDR1 antibody

Information sourced from Uniprot.org

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