Anti-STAB2 antibody (1550-1850) (STJ112114)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal STAB2 (1550-1850) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STAB2 |
| Gene ID | 55576 |
| Uniprot ID | STAB2_HUMAN |
| Immunogen Region | 1550-1850 |
| Immunogen Sequence | GKVCTLINVCLTKNGGCSEF AICNHTGQVERTCTCKPNYI GDGFTCRGSIYQELPKNPKT SQYFFQLQEHFVKDLVGPGP FTVFAPLSAAFDEEARVKDW DKYGLMPQVLRYHVVACHQL LLENLKLISNATSLQGEPIV ISVSQSTVYINNKAKIISSD IISTNGIVHIIDKLLSPKNL LITPKDNSGRILQNLTTLAT NNGYIKFSNLIQDSGLLSVI TDPIHTPVTLFWPTDQALH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1550-1850 of human STAB2 (NP_060034.9). |
Additional Info
| Tissue Specificity | Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line. |
| Post Translational Modifications | Glycosylated. Proteolytically processed to yield a 190 kDa protein. |
| Function | Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Also acts, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS. |
| Protein Name | Stabilin-2Fas1 Egf-Like And X-Link Domain-Containing Adhesion Molecule 2Fasciclin - Egf-Like - Laminin-Type Egf-Like And Link Domain-Containing Scavenger Receptor 2Feel-2Hyaluronan Receptor For Endocytosis Cleaved Into - 190 Kda Form Stabilin-2190 Kda Hyaluronan Receptor For Endocytosis |
| Database Links | Reactome: R-HSA-2160916Reactome: R-HSA-3000497 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmOnly A Small Amount Appears To Be Present At The Cell Surface |
| Alternative Antibody Names | Anti-Stabilin-2 antibodyAnti-Fas1 Egf-Like And X-Link Domain-Containing Adhesion Molecule 2 antibodyAnti-Fasciclin - Egf-Like - Laminin-Type Egf-Like And Link Domain-Containing Scavenger Receptor 2 antibodyAnti-Feel-2 antibodyAnti-Hyaluronan Receptor For Endocytosis Cleaved Into - 190 Kda Form Stabilin-2 antibodyAnti-190 Kda Hyaluronan Receptor For Endocytosis antibodyAnti-STAB2 antibodyAnti-FEEL2 antibodyAnti-FELL antibodyAnti-FEX2 antibodyAnti-HARE antibody |
Information sourced from Uniprot.org