| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-FACT complex subunit SSRP1 (209-259 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SSRP1 |
| Gene ID: | 6749 |
| Uniprot ID: | SSRP1_HUMAN |
| Immunogen Region: | 209-259 aa |
| Specificity: | This antibody detects endogenous levels of SSRP1 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human SSRP1 at the amino acid range 209-259 |
| Function | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. |
| Protein Name | Fact Complex Subunit Ssrp1 Chromatin-Specific Transcription Elongation Factor 80 Kda Subunit Facilitates Chromatin Transcription Complex 80 Kda Subunit Fact 80 Kda Subunit Factp80 Facilitates Chromatin Transcription Complex Subunit Ssrp1 Recombination Signal Sequence Recognition Protein 1 Structure-Specific Recognition Protein 1 Hssrp1 T160 |
| Database Links | Reactome: R-HSA-112382 Reactome: R-HSA-167152 Reactome: R-HSA-167200 Reactome: R-HSA-167238 Reactome: R-HSA-167243 Reactome: R-HSA-167246 Reactome: R-HSA-167287 Reactome: R-HSA-167290 Reactome: R-HSA-674695 Reactome: R-HSA-6796648 Reactome: R-HSA-6804756 Reactome: R-HSA-75955 |
| Cellular Localisation | Nucleus Nucleolus Chromosome Colocalizes With Rna Polymerase Ii On Chromatin Recruited To Actively Transcribed Loci |
| Alternative Antibody Names | Anti-Fact Complex Subunit Ssrp1 antibody Anti-Chromatin-Specific Transcription Elongation Factor 80 Kda Subunit antibody Anti-Facilitates Chromatin Transcription Complex 80 Kda Subunit antibody Anti-Fact 80 Kda Subunit antibody Anti-Factp80 antibody Anti-Facilitates Chromatin Transcription Complex Subunit Ssrp1 antibody Anti-Recombination Signal Sequence Recognition Protein 1 antibody Anti-Structure-Specific Recognition Protein 1 antibody Anti-Hssrp1 antibody Anti-T160 antibody Anti-SSRP1 antibody Anti-FACT80 antibody |
Information sourced from Uniprot.org