| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FACT complex subunit SSRP1 (209-259 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SSRP1 |
| Gene ID: |
6749 |
| Uniprot ID: |
SSRP1_HUMAN |
| Immunogen Region: |
209-259 aa |
| Specificity: |
This antibody detects endogenous levels of SSRP1 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human SSRP1 at the amino acid range 209-259 |
| Function | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. |
| Protein Name | Fact Complex Subunit Ssrp1Chromatin-Specific Transcription Elongation Factor 80 Kda SubunitFacilitates Chromatin Transcription Complex 80 Kda SubunitFact 80 Kda SubunitFactp80Facilitates Chromatin Transcription Complex Subunit Ssrp1Recombination Signal Sequence Recognition Protein 1Structure-Specific Recognition Protein 1Hssrp1T160 |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-167152Reactome: R-HSA-167200Reactome: R-HSA-167238Reactome: R-HSA-167243Reactome: R-HSA-167246Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-674695Reactome: R-HSA-6796648Reactome: R-HSA-6804756Reactome: R-HSA-75955 |
| Cellular Localisation | NucleusNucleolusChromosomeColocalizes With Rna Polymerase Ii On ChromatinRecruited To Actively Transcribed Loci |
| Alternative Antibody Names | Anti-Fact Complex Subunit Ssrp1 antibodyAnti-Chromatin-Specific Transcription Elongation Factor 80 Kda Subunit antibodyAnti-Facilitates Chromatin Transcription Complex 80 Kda Subunit antibodyAnti-Fact 80 Kda Subunit antibodyAnti-Factp80 antibodyAnti-Facilitates Chromatin Transcription Complex Subunit Ssrp1 antibodyAnti-Recombination Signal Sequence Recognition Protein 1 antibodyAnti-Structure-Specific Recognition Protein 1 antibodyAnti-Hssrp1 antibodyAnti-T160 antibodyAnti-SSRP1 antibodyAnti-FACT80 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
